Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients

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  • Sophie Perinel
  • Manon Launay
  • Elizabeth Botelho-Nevers
  • ...
  • Xavier Delavenne
Journal Clin Infect Dis
Date April 7, 2020

A prospective pharmacokinetics study of 13 critical care COVID-19 patients treated with hydroxychloroquine 200 mg three times daily (600 mg daily) showed that the mean time of 2.7 days to achieve the supposed minimum hydroxychloroquine therapeutic threshold of 1 mg/L.

With pharmacokinetic modeling, the study proposes a regimen consisting of a loading dose of hydroxychloroquine 800 mg on day 1 followed by 200 mg twice daily for 7 days to rapidly reach therapeutic levels while not exceeding potentially toxic levels above 2 mg/L.

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This was one of the first studies assessing efficacy of early treatment with hydroxychloroquine and azithromycin in hospitalized COVID-19 patients.

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