Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients

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Publication
Title
Authors
  • Sophie Perinel
  • Manon Launay
  • Elizabeth Botelho-Nevers
  • ...
  • Xavier Delavenne
Journal Clin Infect Dis
Date April 7, 2020

A prospective pharmacokinetics study of 13 critical care COVID-19 patients treated with hydroxychloroquine 200 mg three times daily (600 mg daily) showed that the mean time of 2.7 days to achieve the supposed minimum hydroxychloroquine therapeutic threshold of 1 mg/L.

With pharmacokinetic modeling, the study proposes a regimen consisting of a loading dose of hydroxychloroquine 800 mg on day 1 followed by 200 mg twice daily for 7 days to rapidly reach therapeutic levels while not exceeding potentially toxic levels above 2 mg/L.

Major Issues

No major issues identified at this time.

Minor Issues

No minor issues identified at this time.

Impact

This was one of the first studies assessing efficacy of early treatment with hydroxychloroquine and azithromycin in hospitalized COVID-19 patients.

Article Revisions

None at this time.

References