Risk Factors for Mortality in Patients with COVID-19 in New York City

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  • Takahisa Mikami, MD
  • Hirotaka Miyashita, MD
  • Takayuki Yamada, MD
  • ...
  • Evan Siau, MD
Journal Journal of General Internal Medicine
Date June 30, 2020

Retrospective cohort study of mortality risk factors in 6493 patients with COVID-19 in New York City. Identified risk factors with significant increased mortality were age older than 50 years, systolic blood pressure less than 90 mmHg, respiratory rate over 24 per min, peripheral oxygen saturation less than 92%, estimated glomerular filtration rate under 60 mL/min/1.73m2, IL-6 over 100pg/mL, D-dimer over 2mcg/mL and troponin over 0.03ng/mL. Decreased mortality was associated with female sex, African American race and hydroxychloroquine use.

The Hazard Ratio for hydroxychloroquine use was 0.53 (CI 0.41-0.67) with and without inverse probability weighting based on propensity scoring.

Major Issues

No major issues identified at this time.

Minor Issues

No minor issues identified at this time.


The positive benefit of hydroxychloroquine in this New York analysis challenged the results in the retrospective analysis by Rosenberg et al, which showed no clinical benefit to hydroxychloroquine in hospitalized COVID-19 patients in New York.

Article Revisions

None at this time.