Risk Factors for Mortality in Patients with COVID-19 in New York City
|Journal||Journal of General Internal Medicine|
|Date||June 30, 2020|
Retrospective cohort study of mortality risk factors in 6493 patients with COVID-19 in New York City. Identified risk factors with significant increased mortality were age older than 50 years, systolic blood pressure less than 90 mmHg, respiratory rate over 24 per min, peripheral oxygen saturation less than 92%, estimated glomerular filtration rate under 60 mL/min/1.73m2, IL-6 over 100pg/mL, D-dimer over 2mcg/mL and troponin over 0.03ng/mL. Decreased mortality was associated with female sex, African American race and hydroxychloroquine use.
The Hazard Ratio for hydroxychloroquine use was 0.53 (CI 0.41-0.67) with and without inverse probability weighting based on propensity scoring.
No major issues identified.
No minor issues identified.
The positive benefit of hydroxychloroquine in this New York analysis challenged the results in the retrospective analysis by Rosenberg et al, which showed no clinical benefit to hydroxychloroquine in hospitalized COVID-19 patients in New York.
None at this time.