Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

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Publication
Title
Authors
  • Jia Liu
  • Ruiyuan Cao
  • Mingyue Xu
  • ...
  • Manli Wang
Journal Cell Discovery
Date March 18, 2020

In vitro study demonstrating that hydroxychloroquine is effective in inhibiting SARS-CoV-2 infection by blocking the transport of SARS-CoV-2 from EEs to Els, which is a requirement to release the viral genome. Authors conclude that hydroxychloroquine’s in vitro effect of inhibiting viral replication in combination with its anti-inflammatory function makes the drug a good candidate for treatment of COVID-19.

Major Issues

No major issues identified.

Minor Issues

No minor issues identified.

Impact

This study demonstrated in vitro efficacy of hydroxychloroquine in blocking a necessary step in viral replication of SARS-CoV-2.

Article Revisions

None at this time.

References